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Caffeine absorbed through the mouths lining reaches the bloodstream faster than caffeine that gets swallowed and digested, and that part is established pharmacology

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US Food and Drug Administration, Regulatory Impact Analyses (RIA), accessed July 25, 2025, and US Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation, Guidelines for Regulatory Impact Analysis, January 12, 2017, Abigail Friedman et al., E-Cigarette Flavor Restrictions Effects on Tobacco Product Sales , January 29, 2024, US Food and Drug Administration, Premarket Tobacco Product Applications and Recordkeeping Requirements, Federal Register 86, no