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Manufacturers are focusing on innovation, premiumization, and distribution expansion to maintain growth in an increasingly regulated environment

Despite enormous progress in reducing smoking, tobacco use is still the leading cause of preventable death in the United States and imposes a terrible toll on families, businesses and government

Among these, N-nitrosodimethylamine (NDMA) is a potent hepatocarcinogen that induces DNA alkylation, oxidative stress, and promotes liver fibrosis, ultimately facilitating HCC development [26]

However, lozenges deliver nicotine more slowly and less intensely than smoking, so the experience and impact are different