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Food and Drug Administration (FDA) Commissioner and the Center for Tobacco Products (CTP) Director stated in 2017, Nicotine, though not benign, is not directly responsible for the tobacco-caused cancer, lung disease, and heart disease that kill hundreds of thousands of Americans each year

E cigarette vapour contains ultrafine particles and other substances, which can reach into the lungs and may have different health implications compared to traditional cigarette smoke, though the consensus from public health bodies like Public Health England and Cancer Research UK are that E-Cigarettes are at least 95% less harmful than smoking

These results show that, in developing a reduced-toxicant cigarette design, a balance must be struck between the lower mainstream benzo[a]pyrene, aromatic amine and CO yields (as well as reduced sidestream yields) from reduced circumference cigarettes, and the increased volatile yields resulting from lower adsorbent incorporation