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Your brain adjusts by reducing receptor sensitivity or changing the number of receptors available, explaining why long-term users experience less intense sensations than when they first started

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FDA, FDA authorizes marketing of IQOS tobacco heating system with 'Reduced exposure Information' [press release]

Along with conflicting reports that e-cigs could perpetuate smoking or aid quitting 2,3,4 , the finding that e-cigs may increase smoking initiation has fueled intense debate on the merits and harms of e-cigs 5,6