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Although caffeine is acknowledged to be addictive, producing at least a mild dependency (Hasin et al., 2013), the generally pleasant psychotropic effects and low levels of adverse effects have led to unregulated and widespread use of coffee and other caffeinated beverages (Chou, 1992)

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Dysregulation of cholesterol sulfate desulfation has been implicated in various skin diseases such as X-linked ichthyosis where high levels of cholesterol sulfate are thought to contribute to the impairment of the skin barrier function and desquamation 30