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The graph W vs MEV is zero or close to zero Over-heating , supplied energy surplus increases residual heat at the expense of vaporizing e-liquid, further increasing in each residual heat and decreasing the rate of MEV generation The functional curve displayed in figure 6 below corresponds to a Cubis device with 1 Ohm resistance, 50/50 PG mixture and 12 mg/mL nicotine

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Interestingly, these changes worsened after quitting smoking, with a drop in sex hormone-binding globulin (SHBG) noted as early as the first week of non-smoking