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They found that Exposure to aerosol from HTPs in a designated smoking room under usual conditions is estimated to be tolerable since the lifetime cancer risk is expected to be below a VSD [virtually safe dose] of 10-5 (1/100,000), which is three orders of magnitude lower than that for cigarettes smoked under the same conditions. Research by the Health Service Division of the MHLW, published in the International Journal of Environmental Research and Public Health, compared the concentration of nicotine and particulate matter (PM 2.5 , particles that are 2.5 microns or less in diameter) in the air following 50 puffs from HTPs or cigarettes in a small, unventilated space (a shower cubicle)

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Smokers with this condition have high rates of active otorrhoea and aggressive cholesteatoma with further complications, including exposed dura, exposed facial nerve, and labyrinthine fistulas 16

Provide real-life data on THS users who chose to switch without intervention, showing the importance of replacing smoking with THS use, as the magnitudes of changes were larger than those observed in the exposure response study where concomitant use of cigarettes occurred