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The medication's primary indications remain glycaemic control in type 2 diabetes and, for patients with established cardiovascular disease, reducing the risk of major adverse cardiovascular events
In addition to its role in producing a variety of growth factors and cytokines, such as hepatocyte growth factor (HGF) and transforming growth factor (TGF) (156, 157), the PDAC stroma is known to impede drug delivery through several mechanisms, namely by exerting considerable mechanical force on the intratumoral vasculature and reducing patency (158)
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