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To better simulate the state of daily smoking, mice with good DA signaling in the NAc were administered different concentrations of various nicotine salts by oral and nasal exposure using a smoke tower to observe the effect of nicotine salts on DA release (Figures 1AD)

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Differences in depression symptoms at treatment entry by nicotine use status: There were no differences in depression symptoms between those who reported using nicotine frequently (n = 101, M = 14.63, SD = 6.40) and those who reported not using nicotine products in the last month (n = 808, M =14.19, SD = 6.89), t(907) = -.611, p = .54 Differences in depression symptoms at treatment discharge by nicotine use status: A significant difference emerged at discharge for those who reported frequently using nicotine products