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It acts as a coenzyme in the Krebs cycle and as a cofactor in energy production in the cell

Participants were randomly assigned in a 1:1:1:1 ratio to four intervention groups: acupuncture combined with nicotine patch (ACNP), acupuncture combined with sham nicotine patch (ACSNP), sham acupuncture combined with nicotine patch (SACNP), and sham acupuncture combined with sham nicotine patch (SACSNP)

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It is widely accepted that Californias lower prevalence is attributable at least in part to the intensity of tobacco control efforts in that state (CDC 1996)