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First, reductions in mainstream smoke toxicants were focused on specific toxicant groups: for example, the RTPs containing TSS showed significant reductions in volatile toxicants but had little impact on aromatic amines, benzo[a]pyrene, and involatile phenols (hydroquinone, resorcinol and catechol), whereas the RTP containing BTT showed substantial reductions in most volatiles, and aromatic amines, but had little effect on phenols, isoprene and PAH