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It also wore on Tony Soprano, the mob boss who lived in an upmarket suburban enclave in New Jersey next to doctors and investment bankers and sent his daughter to Columbia, but who confronted the numbing realisation that these totems of his success were also the symbols of his irrelevance

J Radioanal Nucl Chem 323:14251429

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In this case, the company did not provide sufficient evidence of a benefit that outweighs the risk, particularly given evidence that adults who smoke generally do not stop or significantly curtail consumption of cigarettes when using this product. Tobacco products that receive an MDO from the FDA may not be introduced or delivered for introduction into interstate commerce and must be removed from the market