4 harmful chemicals in cigarettes and Tobacco: What's Burning? E-cigarettes, or vapes, contain nicotine

Surprisingly, the researchers found that people who smoked marijuana actually had lower incidences of cancer compared to non-users of the drug

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The same, I think, can and should be said about the occasional moderate use of other substances (i.e., alcohol), though obviously not all other substances, since some are so inherently addictive and destructive that they should never be meddled with