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Building on multiple Phase 1 and Phase 2 clinical studies in both healthy people and people with a variety of clinical conditions showing safety of carbon monoxide at the low doses studied here, a clinical trial of low-dose, orally administered carbon monoxide in patients with Parkinsons disease is planned. Disclosures: There are relevant COI disclosures

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It is safest to abstain from smoking hookah since tobacco use is one of the leading risk factors for oral cancer

These items may also cause irritation and slow the healing process