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Cooling agents were added to fruit-flavored E-liquids named Orange Ice and Blueberry Ice, but also Strawberry Banana and Lychee, without the Ice label, and in Cucumber and OMG flavors

MR is based on three key assumptions: 1) the genetic variants used as instruments for the exposure must be valid and robustly associated with the exposure, 2) there should be no measured or unmeasured confounding of the association between the genetic instrument and the outcome, and 3) the variants should have no independent effect on the outcome other than through the exposure of interest 17

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