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As the number of OMP + mature ORNs is determined by the balance between the cell death of ORNs and the regeneration of ORNs from ORN progenitors, we next investigated the effects of cigarette smoke on the number of ORN progenitors, immature ORNs and dividing cells, and on cell death in the aged mice, by examining SOX2 expression, GAP43, Ki67, and cleaved caspase-3

Benam, a Wyss Institute technology development fellow

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It also has a smoking rate of 20.4 percent, almost three times higher than Hawaii, the state with the lowest smoking rate.