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When the substance binds with nicotinic acetylcholine receptors on chromaffin cells, it opens ion channels that follow the same depolarization path to release epinephrine into the bloodstream

Tobacco smoke is also filtered, but marijuana smoke is not

Our findings suggest that the unique way vapers and hookah smokers use their devices may expose the nose and sinuses to far more emissions than cigarettes, which may in turn increase their risk for upper respiratory diseases, says study lead author Emma Karey, PhD, a postdoctoral research fellow in the Department of Medicines Division of Environmental Medicine at NYU Langone Health