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& Paronis, C

ZYN eliminates combustion, meaning users avoid: Tar Carbon monoxide Smoke-related toxins However, nicotine itself still has effects: Raises heart rate and blood pressure Can reinforce addiction May affect developing brains (especially under age 25) Can irritate gums and oral tissue Smoother or smoke-free does not mean risk-free

Combined usage of cigarettes and HTPs has decreased over time and thus does not seem to be a predominant use pattern in Japan Looking at the patterns of tobacco product use among adults (aged 20 and older) shows that, over time, the proportion of HTP users who do not smoke has increased, reaching 65% in 2023

A review of CLU working group