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Nicotine also affects the systems that release other neurochemicals like noradrenaline and serotonin, leading to different experiences in mood, reward, and decision-making for teenagers compared to adults 38-40 Alternative tobacco and nicotine products are often designed to appeal to adolescents through lifestyle branding and flavours Adolescent brains are more susceptible to impulsive decision making 40 Younger age groups are more likely to continue usage (obtaining greater pleasure from nicotine use than older age groups) Nicotine has been associated with decreased academic performance and higher drop out rates in youth 41 If your patients do not smoke, they shouldn't use alternative tobacco or nicotine products Nicorette is licensed to help smokers or vapers to quit and can be used in children from the age of 12 Unlike alternative tobacco and nicotine products, NRT: NRTs are licensed medicines: 1-3 Licensed, with a good safety profile and a defined dosing schedule for cessation Clinically indicated to relieve and/or prevent cravings and nicotine withdrawal symptoms associated with tobacco dependence Pharmaceutical grade nicotine in measured doses 29 NRT is designed and acknowledged to help patients become smoke and nicotine free: 1-3 ** Endpoint aim of complete cessation Many clinical guidelines globally recommend NRT as a first-line treatment for smoking cessation 42-44 On the WHO list of essential medicines 43 **Abstinence rates: Combination Therapy (nicotine patch + active gum): 27.5% vs nicotine patch + placebo gum: 15.3% p=0.01, at 24 weeks

Applications Claiming Priority (2) Publications (1) Family ID=11408288 Family Applications (1) Country Status (2) Cited By (6) Citations (12) 1998 1998-06-11 IT ITSV980036 patent/IT1305964B1/en active 1999 1999-06-04 EP EP99110736A patent/EP0963913A1/en not_active Withdrawn

Dagaonkar RS, R.S

Vivienne Nathanson: It was about getting the public and politicians to a stage of recognising that this was something that could be done