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20 IL-8 is a cytokine involved in neutrophil recruitment while HBD-2 is an effector molecule that is effective in killing gram negative bacteria and has a bacteriostatic effect on gram positive bacteria such as Staphylococcus and Streptococcus

Therefore, the present findings in a sedentary mouse model of emphysema have important translational impact for the vast majority of sedentary individuals with chronic lung disease and provide a strong impetus for early implementation of physical rehabilitation strategies after COPD diagnosis