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When people adjust the voltage of a device or add substances to the liquid, they can increase their exposure to harmful chemicals like heavy metals. She noted that some of the modifications the study identified were benign and even intended like replacing a battery or heating coil with an authorized part but that 68% and 61% of youth and young adults, respectively, made modifications to the e-liquid such as making their own flavorings, adding additional nicotine or adding cannabis

As of May 2021, there are eleven approved warnings