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Principal coordinate analysis (PCoA) based on BrayCurtis inter-sample distance (PERMANOVA R 2 = 0.0413, p -value = 0.001) and unweighted UniFrac intersample distance (PERMANOVA, R 2 = 0.0454, p-value = 0.001) matrices showed clear separation between healthy and OSCC samples ( Figure 1C

the fields are divided by walls of the limestone which abounds thereabout, and are well cultivated

6 Across the population, a third (33%) of people living in the two most deprived deciles of England in 2021 were smokers, compared to 10% of those in the two least deprived areas

Captain Black Red had the most dramatic development of these three tobaccos, being very cherry dominate in the first half, then switching to essentially the same profile as Captain Black Original for the remainder of the bowl with just a hint of cherry