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For example, someone who smoked two packs per day for 10 years may have a higher risk than someone who smoked one pack per day for 20 years, even though both have 20 pack years

Components of Smoke Disrupt Immune Function Awad adds, We suspected that some of the more than 20,000 chemicals present in cigarette smoke that smokers inhale might also bind to MR1 and influence the activity of MAIT cells in the lungs. The researchers used computer modeling to predict which components of cigarette smoke might be recognized by MR1 and found that several of these molecules not only bound to the protein but also either increased or decreased its amounts on the surface of cells

However, a rise in vaping among adolescents and young adults has been observed over the past several years due to the increased availability of disposable devices