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Among the hazards are: Benzo(a)pyrene Benz(a)anthracene Phenols Vinyl chlorides Nitrosamines Reactive oxygen species People also smoke marijuana in a different way than they smoke tobacco, possibly posing greater danger to the lungs: Some people hold in weed smoke as long as possible to get "higher," but that's a myth

Or, as N.Hill says, inside it live two different persons/entities

Additionally, there are other chemicals in the admixture aside from nicotine and the long term negative issues of being exposed to the other chemicals are not known