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It may alter how the liver metabolizes certain drugs, which could lead to higher or lower concentrations of the medication in the bloodstream

J Am Coll Cardiol 2009

With their nicotine salts, Juul has found the Holy Grail. In response, Juul did not directly address that accusation, but said its product offered a public health and commercial opportunity of historic proportions for the millions of adult smokers who die each year from cigarettes

However, we have yet to validate these findings in an in vivo model and fully elucidate the mechanisms by which cigarette smoke downregulates ABCA1 expression in airway epithelial cells