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Of note, another study indicated that although RANTES/CCL5 and CCR1 mRNA were upregulated in flavour/nicotine-containing e-cigarette users, vaping flavour and nicotine-less e-cigarettes did not significantly dysregulate cytokine and inflammasome activation [43]

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This direct exposure damages cells and increases the likelihood of mutations that can lead to cancer.The Nature Communications study highlighted that even moderate use of chewing tobacco over time can result in precancerous lesions and a faster progression to malignant tumors compared to cigarette smoking

Now, some states are stepping up and restricting the age at which their own resident can purchase tobacco products, and other states could follow, making it a trend at the state legislative level