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These diseases, such as lung cancer, cardiovascular disease and emphysema, are caused primarily by inhaling harmful compounds formed when tobacco is burned

66,67 Therefore, miRNAs should not be seen as independent diagnostic markers, but rather as possible parts of multi-marker panels that may better reflect OA heterogeneity, including inflammatory phenotypes that may be more common in smoking-related disease

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While e-cigarettes are generally considered less harmful, its essential to recognize that they still contain nicotine and users should remain informed about health implications