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Representative terms included addiction, alkaloids, anthraquinones, arecoline, arecoline pathway, betel nut, betel nut components, betel quid, bromophenols, cessation, chromenones, coumarins, dependence, fatty acids, flavonoids, MAO -A, MAO inhibitors, MAO inhibitors in betel nut, MAO inhibitors in smoking and smokeless tobacco, MAO gene structure, mAChR, monoamine oxidase, nAChR, phenols, polyphenols, prevalence, saponins, sterols, tannins, terpenoids, treatment, and xanthones. The inclusion criteria were original research articles, review articles, meta-analyses, and clinical studies published in peer-reviewed journals on betel quid, betel nut, arecoline, monoamine oxidases, addiction pathways (arecoline and nicotine in smoking and smokeless tobacco), MAO inhibitors in smoking and smokeless tobacco, prevalence, epidemiology, cessation, and interventions

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