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It has been shown that cigarette smoke upregulates ACE2 in a dose-dependent manner in lung epithelium, including the goblet, club, Clara cells, and alveolar type 2 (AT2) cells of human and rodent lungs, and quitting smoking decreases ACE2 expression (reversible) [13]

Clinically occult interstitial fibrosis in smokers: classification and significance of a surprisingly common finding in lobectomy specimens

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According to a study published in the Tobacco Induced Diseases journal, five major T,TCs such as Philip Morris International, British American Tobacco, Japan Tobacco International, Imperial Brands, and China National Tobacco Corpora,tion shall dominate the international tobacco industry