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Since the activity of CYP1A2 varies greatly from individual to individual, literature evidenced that there are different influential factors, such as genetics, coffee consumption, oral contraceptive use and smoking, even if the mechanisms are complex and not completely clear [21]

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Isomenthone, another oxygenated monoterpene, was only detected in green grape (EG) flavored hookah tobacco aroma profile at low level of 2%, which is used as a fragrance in many cosmetic products with wounding healing effect and was found to have a protective effect on fibroblast, cells of connective tissue, from tumor necrosis factor (TNF)--induced death 38

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