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[...] It is reasonable to conclude that if used as a substitute rather than an addition, e-cigarettes are much less harmful than continuing to smoke.[xxi] Cochrane Review : The gold-standard systematic review of randomised controlled trials has concluded that for every 100 people using nicotine ecigarettes to stop smoking, 9 to 14 might successfully stop, compared with only 6 of 100 people using NRT, 7 of 100 using nicotinefree ecigarettes, or four of 100 people having no support or behavioural support only.[xxii] US Federal Drug Administration : The FDA has granted a number of Premarket Tobacco Product Applications (PMTAs)[xxiii] and Modified Risk Tobacco Product orders (MRTPs)[xxiv] for safer nicotine products in the US

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