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A pharmacokinetic study showed that TS increased clearance of olanzapine by 23% because of the induction of CYP1A2 enzyme activity in the liver (Ng et al., 2009)

It is unclear whether this association is due to confounding factors such as more sex partners among smokers compared with nonsmokers, or to a direct biologic effect through suppressed immune function in smokers (Holt 1987)

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