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It is believed that increased oxidative stress induced by cigarette smoke may reduce the bioavailability of endothelium-derived nitric oxide (NO), a molecule that helps to relax the smooth muscles of endothelium (inner lining of blood vessels.) Vitamin C improves endothelial function and blood vessel relaxation possibly through a combination of different mechanisms, for example by destroying superoxide radicals, protecting intracellular glutathione or increasing the production of NO synthesis in human endothelial cell [7]

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