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What has been lacking until now among individuals with and without psychiatric disorders is a large, randomised controlled trial that directly compares these medications with placebo and an active comparator, and that systematically probes for neuropsychiatric adverse events while smokers are trying to quit. The researchers assessed the relative neuropsychiatric safety and efficacy of varenicline and bupropion compared with nicotine patches and placebo among 8,144 smokers with or without psychiatric illnesses

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at age 15 years or later

But even he didnt think hed be able to persevere if the public didnt back him up all the way, right from the start