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They have been marketed as an appealing alternative to spit tobacco because there is no need to spit (like with chewing tobacco), and the pouches do not produce odor, smoke or vapor

Ectopic Pregnancy Ectopic pregnancy is a life-threatening reproductive complication that is more likely in those who smoke

Specifically, we are proposing to codify that in cases where negative or zero ASP data is reported for some, but not all, NDCs of a multiple source drug, we would calculate the payment limit using the positive ASP data reported for the drug, except for the existing carryover policy for multiple source drugs that we would apply when missing data results in a significant change in the ASP payment limit

(a) Supplying fees