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We investigated with voltage-clamp experiments, effects of aqueous extracts (coffees) of unroasted and roasted coffee beans on the activity of human brain nicotinic acetylcholine receptor (nAChR) subtypes expressed in Xenopus oocytes, looking at complex brews, low molecular weight (LMW) fractions, and specific compounds present in coffee

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According to CDC data, consumption of noncigarette combustible tobacco (cigars, roll-your-own, pipe tobacco) increased 117.1% between 2000 and 2015, while total cigarette consumption decreased 38.7% during the same period