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It affects gamma-aminobutyric acid (GABA) which can cause relaxation but long term use of alcohol can affect your levels of GABA or glutamate in the nervous system

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In fact, a small 2020 study of regular cannabis users found multiple blood markers related to metabolism in participants' blood after they either smoked, vaporized, or ingested cannabis vs

Diagnoses for alcohol use disorder (AUD) and cannabis use disorder (CUD) must meet certain criteria in the DSM-5, professional reference book on mental health and brain-related conditions