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Tashkin DP, Rennard SI, Martin P, Ramachandran S, Martin UJ, Silkoff PE, Goldman M: Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial

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A direct approach to determine/assess nicotine dependence would be to inquire about wanting, craving and needing and their respective latencies." The suggestion that nicotine dependence can be reduced to craving is contradicted by converging lines of empirical evidence