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These differences arise from a combination of the quantity of each toxicant present in the cigarette smoke entering the filter (in which isoprene, acetaldehyde and acetone are the major constituents by mass concentration) and the efficiency of HAC towards individual smoke constituents

Both the guidance to the final rule and the preamble that introduces it recognize that smokers with certain mental health conditions may need special attention to ensure that they understand the smoke-free policy and how to use any resources offered to help them stop smoking

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