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some medications can be more effective for some smokers if used over a longer pre-quit and for others, if used over an extended post-quit period We have also shown that some early limits on using stop-smoking medications were over-cautious and that some medications, such as varenicline, can be more effective for some smokers if used over a longer pre-quit and for others, if used over an extended post-quit period and that nicotine replacement treatment can be used safely over long term