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Interestingly, most of the genera present in tobacco products were found to overlap (in terms of presence and absence) with differentially abundant genera of OSCC buccal site (compared to healthy buccal controls), smokeless-tobacco-consuming healthy buccal site (compared to tobacco non-consumers), and OSCC tumor site (compared to contralateral healthy buccal site of OSCC samples) ( Supplementary Figure S12A )