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The applicant stated that although the number of inpatient hospitalized individuals receiving a treatment cycle with Dara-CyBorD is expected to be low, it is important to ensure health care equity and access to the only FDA approved drug for treatment of newly diagnosed AL amyloidosis, regardless of treatment setting

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Some researchers and policymakers are concerned about the order in which the initiation of tobacco products takes place, positing that the use of e-cigarettes could increase the likelihood that adolescents and young adults who have never used any tobacco products, but initiate e-cigarettes, will become lifetime users of conventional cigarettes or other tobacco products in sufficiently large numbers, resulting in a net harm to public health (USDHHS 2012)