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The multivariable-adjusted model was adjusted for age (time scale), sex, year of screening examination, study center, obesity, smoking status, regular exercise, alcohol intake, educational level, family history of cancer, medication for hyperlipidemia, history of diabetes, history of hypertension, and history of CVD, Estimated from Cox proportional hazard models with inverse probability weights with colonoscopic screening, obesity, smoking status, regular exercise, alcohol intake, educational level, medication for hyperlipidemia, history of diabetes, history of hypertension, and history of CVD as time-dependent variables and baseline age, sex, study center, year of screening examination, education level, and family history of cancer as time-fixed variables