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Born in 1897, the contralto represents the culmination of hundreds of years of musical transmission and development along with the continuously evolving nature of American Culture

While mortality, hospitalizations, and disease severity are important measures of COPD burden, assessment of the quality of life of individuals with COPD is an accepted major outcome in observational trials of COPD as it readily captures the impact of disease on daily life and is a reliable predictor of disease progression and mortality