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Although evidence for the cardiopulmonary toxicity of chronic e-cig use is largely restricted to animal studies, investigations in both animals and humans indicate that e-cigs promote hypertension, autonomic imbalance, and vascular dysfunction via nicotine and/or flavors 14,15,16,17,18

Safety certifications including UL, FCC, and CE confirm its secure handling, although users must follow instructions carefully to avoid polarity errors

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The research team assessed 6,473 adults (4,635 men and 1,838 women) aged between 45 and 69 years old over a 10-year period