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Previous ICSS studies have observed that chronic exposure to drugs sensitizes the brain reward system, and in doing so lowers the stimulation threshold (expressed as a current intensity or stimulation frequency) 46 required for ICSS 47

Signage requirements for non-smoking areas are as follows: Signage can either read No Smoking or use the international No Smoking symbol (pictorial representation of a burning cigarette enclosed in a red circle with a red bar across it) and need to be clearly and conspicuously posted wherever smoking is prohibited

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