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Conclusions Among women with a history of combustible cigarette smoking prior to pregnancy, there was no indication that e-cigarette use helped pregnant women to reduce their combustible cigarette consumption or resulted in observable fetal health benefits

Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 The cotinine concentration [ng/ml] in urine or rats after vapor (group 2), smoke (group 3) or saline (group 1) exposure in different weeks of experiment

Symptoms of nicotine withdrawal include, but are not limited to, cravings, headaches, insomnia, increased appetite, cough, and fatigue