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1.76 v 1.58 for five cigarettes per day), consistent with a higher risk of coronary heart disease in women reported by others.73 A comparison between sexes could also be examined directly within the same study cohort, where a higher relative risk was seen, without modelling: Hirayama et al (relative risk 1.61 for women versus 1.50 for men, for smoking one to four cigarettes per day),29 Nilsson et al (1.47 v 1.24, for smoking one to seven cigarettes per day),53 Prescott et al (2.14 v 1.03, for smoking three to five cigarettes per day),72 and Bjartveit et al (2.94 v 2.74, for smoking one to four cigarettes per day).17 Supplementary figure D shows the forest plots for the age and sex adjusted relative risks in five studies for which results were not reported separately by sex: consuming one or five cigarettes per day had 53% or 61% of the excess risk, compared with 20 cigarettes per day (table 1)

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