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Addictive drugs all act on a part of the brain that is described as the central reward circuitry.' Once this system is exposed to one drug, the brain may become more sensitive to the effects of other drugs, as demonstrated by a number of rodent studies

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Upon exposure to pro-inflammatory signals such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-) cytokines, M1 macrophages activate further pro-inflammatory responses such as additional cytokines, neutrophils and T cells that produce a heightened inflammatory response at the site of infection or injury