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Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26

Beyond atherosclerosis, GLP-1R-targeted NPs have been evaluated in MI and heart failure

Hospitalization for unstable angina and coronary revascularization were analyzed separately and were not included in the composite endpoint

PT-141 Injections vs Nasal Spray: Safety and Side Effects Side Effects and Safety Common Side Effects : Mild headache Nausea Flushing Rare Side Effects : Dizziness (moderate) Increased heart rate (severe) Safety Summary : PT-141 Injections have a generally safe profile when used as directed